Multi-voxel algorithm for quantitative bi-exponential MRI T1 estimation

TitleMulti-voxel algorithm for quantitative bi-exponential MRI T1 estimation
Publication TypeConference Paper
Year of Publication2016
AuthorsP. Bladt, G. Van Steenkiste, G. Ramos-Llordén, A J. den Dekker, and J. Sijbers
Conference NameSPIE Medical Imaging
Conference LocationSan Diego, California, United States of America

In this work, we propose a joint multi-voxel bi-exponential estimator (JMBE) for quantitative bi-exponential T1 estimation in magnetic resonance imaging, to account for partial volume effects and to yield more accurate results compared to single-voxel bi-exponential estimators (SBEs). Using a numerical brain phantom with voxels containing two tissues, the minimal signal-to-noise ratio (SNR) needed to estimate both T1 values with sufficient accuracy was investigated. Compared to the SBE, and for clinically achievable single-voxel SNRs, the JMBE yields accurate T1 estimates if four or more neighboring voxels are used in the joint estimation framework, in which case it is also efficient.